In this thesis we address the numerical approximation of the incompressible Navier-Stokes equations evolving in a moving domain with the spectral element method and high order time integrators. First, we present the spectral element method and the basic tools to perform spectral discretizations of the Galerkin or Galerkin with Numerical Integration (G-NI) type. We cover a large range of possibilities regarding the reference elements, basis functions, interpolation points and quadrature points. In this approach, the integration and differentiation of the polynomial functions is done numerically through the help of suitable point sets. Regarding the differentiation, we present a detailed numerical study of which points should be used to attain better stability (among the choices we present). Second, we introduce the incompressible steady/unsteady Stokes and Navier-Stokes equations and their spectral approximation. In the unsteady case, we introduce a combination of Backward Differentiation Formulas and an extrapolation formula of the same order for the time integration. Once the equations are discretized, a linear system must be solved to obtain the approximate solution. In this context, we consider the solution of the whole system of equations combined with a block type preconditioner. The preconditioner is shown to be optimal in terms of number of iterations used by the GMRES method in the steady case, but not in the unsteady one. Another alternative presented is to use algebraic factorization methods of the Yosida type and decouple the calculation of velocity and pressure. A benchmark is also presented to access the numerical convergence properties of this type of methods in our context. Third, we extend the algorithms developed in the fixed domain case to the Arbitrary Lagrangian Eulerian framework. The issue of defining a high order ALE map is addressed. This allows to construct a computational domain that is described with curved elements. A benchmark using a direct method to solve the linear system or the Yosida-q methods is presented to show the convergence orders of the method proposed. Finally, we apply the developed method with an implicit fully coupled and semi-implicit approach, to solve a fluid-structure interaction problem for a simple 2D hemodynamics example.