Medium-voltage conversion systems, such as traction and grid-connected converters, are continuously evolving toward higher power densities. Consequently, volume, weight, and material reductions are becoming major design issues, which lead the research focus toward high-/medium-frequency isolated power conversion systems. An optimized design of these conversion systems requires a detailed transformer-loss evaluation considering both copper and core losses. This paper presents a simple and flexible methodology to analyze global medium-frequency transformer losses in an isolated dc–dc converter fed by general nonsinusoidal waveforms. Various loss evaluation approaches are considered, pointing out their validity and limitations by means of finiteelement simulations and experimental tests.