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research article

Bioorganometallic chemistry-from teaching paradigms to medicinal applications

Hartinger, Christian G.
•
Dyson, Paul J.  
2009
CHEMICAL SOCIETY REVIEWS

In undergraduate level organometallic chem. courses students are usually taught that organometallic compds. are toxic and unstable in air and water. While this is true of many complexes, some are also non-toxic and stable in air and water. Indeed, bioorganometallic chem., the study of biomols. or biol. active mols. that contain at least one carbon directly bound to a metal, is a thriving subject, and air and water stability is a general pre-requisite. This interdisciplinary field is located at the borderline between chem., biochem., biol. and medicine. In this tutorial review, various aspects of bioorganometallic chem. are introduced, with the main emphasis on medicinal organometallic compds. Organometallic therapeutics for cancer, HIV and malaria and other medicinal applications are described. It is also shown how rational ligand design has led to new improved therapies much in the same way that an organometallic chemist working in catalysis will design new ligands for improved activities.

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Type
research article
DOI
10.1039/b707077m
Web of Science ID

WOS:000264374600007

Author(s)
Hartinger, Christian G.
Dyson, Paul J.  
Date Issued

2009

Published in
CHEMICAL SOCIETY REVIEWS
Volume

38

Issue

2

Start page

391

End page

401

Subjects

Half-Sandwich Complexes

•

Anticancer Drugs

•

Antitumor-Activity

•

Organometallic Chemistry

•

Titanocene Dichloride

•

Ruthenium Complexes

•

Electron-Transfer

•

Breast-Cancer

•

Cell Lines

•

Protein

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
LCOM  
Available on Infoscience
June 11, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/40412
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