Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.


Published in:
Journal of Virology, 83, 11, 5574-5580
Year:
2009
Publisher:
American Society for Microbiology
ISSN:
0022-538X
Keywords:
Laboratories:




 Record created 2009-05-25, last modified 2018-12-03


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