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research article
Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications
2009
KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.
Type
research article
Web of Science ID
WOS:000266034100027
Authors
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Laurenti, Elisa
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Verp, Sonia
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Padrun, Viviane
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Trumpp, Andreas
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Publication date
2009
Publisher
Published in
Volume
83
Issue
11
Start page
5574
End page
5580
Peer reviewed
REVIEWED
Available on Infoscience
May 25, 2009
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