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research article
CMOS DNA sensor array with integratedA/D conversion based on label-free capacitance measurement
This paper presents a fully electronic label-free DNA chip in 0.5-mu m CMOS technology, with 5-V supply voltage, suitable for low-cost highly integrated applications. The chip features an array of 128 sensor sites with gold electrodes and integrated measurement, conditioning, multiplexing and analog-to-digital conversion circuitry. The circuits measure capacitance variations due to DNA hybridization on the gold electrodes which are bio-modified by covalently attaching probes of known sequence. Specificity, repeatability and parallel detection capability of the fabricated chip are successfully demonstrated.
Type
research article
Authors
Stagni, C.
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Benini, L.
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Ricco, B.
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Carrara, S.
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Samori, B.
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Paulus, C.
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Schienle, M.
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Augustyniak, M.
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Thewes, R.
Publication date
2006
Published in
Volume
41
Issue
12
Start page
2956
End page
2964
Peer reviewed
REVIEWED
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May 12, 2009
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