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PGC-1alpha plays essential and diverse functions in the control of metabolism ranging from mitochondrial biogenesis and respiration to hepatic gluconeogenesis and muscle fiber-type switching. In a paper in this issue of Cell, the characterization of PGC-1alpha(-/-) mice illustrates these pleiotropic functions and reveals an unexpected role for PGC-1alpha in the brain.
Type
review article
PubMed ID
15454076
Authors
Publication date
2004
Published in
Volume
119
Issue
1
Start page
5
End page
7
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 2, 2009
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