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review article
DisSIRTing on LXR and cholesterol metabolism
2007
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.
Type
review article
PubMed ID
17983578
Authors
Publication date
2007
Published in
Volume
6
Issue
5
Start page
343
End page
5
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 2, 2009
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