DisSIRTing on LXR and cholesterol metabolism

The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.


Published in:
Cell metabolism, 6, 5, 343-5
Year:
2007
ISSN:
1550-4131
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Note: The status of this file is: Involved Laboratories Only


 Record created 2009-04-02, last modified 2018-01-28

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