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review article
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.
Type
review article
PubMed ID
11463572
Authors
Publication date
2001
Published in
Volume
27
Issue
1
Start page
1
End page
9
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 2, 2009
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