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  4. Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells
 
research article

Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells

Mascrez, Bénédicte
•
Ghyselinck, Norbert B
•
Watanabe, Mitsuhiro
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2004
EMBO reports

We show that mice expressing retinoid X receptor beta (RXRbeta) impaired in its transcriptional activation function AF-2 (Rxrb(af20) mutation) do not display the spermatid release defects observed in RXRbeta-null mutants, indicating that the role of RXRbeta in spermatid release is ligand-independent. In contrast, like RXRbeta-null mutants, Rxrb(af20) mice accumulate cholesteryl esters in Sertoli cells (SCs) due to reduced ABCA1 transporter-mediated cholesterol efflux. We provide genetic and molecular evidence that cholesterol homeostasis in SCs does not require PPARalpha and beta, but depends upon the TIF2 coactivator and RXRbeta/LXRbeta heterodimers, in which RXRbeta AF-2 is transcriptionally active. Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid.

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Type
research article
DOI
10.1038/sj.embor.7400094
PubMed ID

14993927

Author(s)
Mascrez, Bénédicte
Ghyselinck, Norbert B
Watanabe, Mitsuhiro
Annicotte, Jean-Sébastien
Chambon, Pierre
Auwerx, Johan  
Mark, Manuel
Date Issued

2004

Published in
EMBO reports
Volume

5

Issue

3

Start page

285

End page

90

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LISP  
Available on Infoscience
April 2, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/36678
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