PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter

PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.


Published in:
FEBS letters, 438, 1-2, 55-60
Year:
1998
ISSN:
0014-5793
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 Record created 2009-04-02, last modified 2018-01-28


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