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research article
PPARgamma3 mRNA: a distinct PPARgamma mRNA subtype transcribed from an independent promoter
1998
PPARgamma is a member of the peroxisome proliferator activated receptors (PPAR) subfamily of nuclear receptors. So far two PPARgamma isoforms, PPARgamma1 and PPARgamma2, were known in mammals. We describe the structure of a novel human PPARgamma subtype, PPARgamma3. The PPARgamma3 mRNA is transcribed from a novel promoter localized 5' of exon A2. PPARgamma3 mRNA expression was restricted to adipose tissue and large intestine. Similar to human PPARgamma1 and -2, PPARy3 is activated by thiazolidinediones and prostaglandin J derivatives and binds with high affinity to a PPRE.
Type
research article
PubMed ID
9821958
Authors
Publication date
1998
Published in
Volume
438
Issue
1-2
Start page
55
End page
60
Subjects
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
April 2, 2009
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