Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit
 
research article

Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit

Debril, Marie-Bernard
•
Gelman, Laurent
•
Fayard, Elisabeth
Show more
2004
Journal of Biological Chemistry

Transcriptional activity relies on coregulators that modify chromatin structure or serve as bridging factors between transcription factors and the basal transcription machinery. We identified a new coregulator of peroxisome proliferator-activated receptor gamma, BRG1/Brm-associated factor of 60 kDa, subunit c2 (BAF60c2), in a yeast two-hybrid screen of a human adipose tissue cDNA library. BAF60c2 represents a new isoform of BAF60c, a component of the SWI/SNF (mating type switching/sucrose non-fermenting) chromatin remodeling complex. This new isoform as well as the previously identified protein, renamed BAF60c1, is localized primarily in the cell nucleus and is expressed in a wide variety of tissues. Both BAF60c isoforms bind to several nuclear receptors and transcription factors of various families. BAF60c proteins interact in a ligand-independent manner with peroxisome proliferator-activated receptor gamma and enhance its transcriptional activity. Both isoforms are enriched in the central nervous system and also modulate the transcriptional activity of retinoic acid-related orphan receptor alpha1. In conclusion, BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors.

  • Details
  • Metrics
Type
research article
DOI
10.1074/jbc.M312288200
PubMed ID

14701856

Author(s)
Debril, Marie-Bernard
Gelman, Laurent
Fayard, Elisabeth
Annicotte, Jean-Sébastien
Rocchi, Stéphane
Auwerx, Johan  
Date Issued

2004

Published in
Journal of Biological Chemistry
Volume

279

Issue

16

Start page

16677

End page

86

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
LISP  
Available on Infoscience
April 2, 2009
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/36602
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés