Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation

LRH-1 is an orphan nuclear receptor predominantly expressed in tissues of endodermal origin, where it controls development and cholesterol homeostasis. We show here that LRH-1 induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin. Whereas beta-catenin coactivates LRH-1 on the cyclin E1 promoter, LRH-1 acts as a potent tissue-restricted coactivator of beta-catenin on the cyclin D1 promoter. The implication of LRH-1 in cell proliferation highlights an unanticipated crosstalk between LRH-1 and the beta-catenin/Tcf4 signaling pathway, which is relevant for the renewal of intestinal crypt cells.


Published in:
Molecular cell, 15, 4, 499-509
Year:
2004
ISSN:
1097-2765
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Note: The status of this file is: Involved Laboratories Only


 Record created 2009-04-02, last modified 2018-09-13

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