We propose a Fourier analytical condition linking alias-free sampling with the Fourier transform of the indicator function defined on the given frequency support. Our discussions center around how to develop practical computation algorithms based on the proposed analytical condition. We address several issues along this line, including the derivation of simple closed-form expressions for the Fourier transforms of the indicator functions defined on arbitrary polygonal and polyhedral domains; a complete and nonredundant enumeration of all quantized sampling lattices via the Hermite normal forms of integer matrices; and a quantitative analysis of the approximation of the original infinite Fourier condition by using finite computations. Combining these results, we propose a computational testing procedure that can efficiently search for the optimal alias-free sampling lattices for a given polygonal or polyhedral shaped frequency domain. Several examples are presented to show the potential of the proposed algorithm in multidimensional filter bank design, as well as in applications involving the design of efficient sampling patterns for multidimensional bandlimited signals.