Scale-up of polymerization processes

A review. Scale-up and/or scale-down procedures are crucial during the development of chem. processes. These procedures should be integrated to form a multidisciplinary approach encompassing several branches of science and engineering. The challenge is to find a balance between chem., design, environment, hygiene and safety (EHS) compliance and economic factors. The iterative process of scale-up procedures also requires concept discrimination at early stages of process development. Scale-up studies should predict the reactor behavior and the quality and properties of a product from lab. and pilot plant to full scale; however, not every pilot scale presents a valid industrial scaled-down size. A rational math. model describing the process reasonably well for large scale is important for designing industrial processing units, but this is only feasible if a phenomenol. understanding is achieved, and if the necessary consts. and parameters are estd. accurately. An accomplished process development procedure must lead to products presenting the same properties at both small and large scale.

Published in:
Current Opinion in Drug Discovery & Development, 5, 6, 960-965
CAN 138:271988
Chemistry of Synthetic High Polymers
Institute of Chemical and Biological Process Science,Swiss Federal Institute of Technology,Lausanne,Switz.
Journal; General Review
written in English.
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 Record created 2009-02-09, last modified 2020-07-30

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