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research article
A Short and Convenient Synthesis of 1-Deoxymannojirimycin (DMJ) and N-oxy-Analogues from D-Fructose
The ketonitrone 8 was prepared from D-fructose as an inexpensive starting material, and was used in a stereoselective synthesis of 1-deoxymannojirimycin (4), its previously unknown N-hydroxy analogue 15, as well as the polyhydroxylated ketonitrone 14. The latter were assayed as potential glycosidase inhibitors on a panel of 13 selected purified enzymes. N-Hydroxy DMJ (15) exhibited a moderate and non selective activity towards the snail - mannosidase EC 3.2.1.25.
Type
research article
Web of Science ID
WOS:000263316600049
Authors
Publication date
2009
Published in
Volume
74
Start page
1766
End page
1769
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
January 16, 2009
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