Preparation of porphyrin and phthalocyanine organometallic compounds for the treatment of cancer
The present invention relates to novel organometallic compds. for use as a medicine, in particular in photodynamic therapy against various diseases, such as cancer. The compds. comprise a central porphyrin or phthalocyanine backbone to which ligand linkers coordinated to at least one transition metal are attached. Eta-5 or eta-6 arenes further bind to the transition metal. According to a preferred embodiment, the compd. is a tetranuclear Ruthenium (+II) complex. Thus, reaction of [Ru(η6-C6H6)(μ-Cl)Cl]2 with 5,10,15,20-(pyrid-4-yl)porphyrin (TPP) in refluxing MeOH gave 56% title compd., [Ru4(η6-C6H6)4(TPP)Cl8].
38121677
Alternative title(s) : (de) Metallorganische verbindungen (fr) Composés organométalliques (en) Organometallic compounds
Patent number | Country code | Kind code | Date issued |
US2010173885 | US | A1 | 2010-07-08 |
JP2010516754 | JP | A | 2010-05-20 |
EP2114978 | EP | A1 | 2009-11-11 |
AU2008208582 | AU | A1 | 2008-07-31 |
CA2676535 | CA | A1 | 2008-07-31 |
WO2008090526 | WO | A1 | 2008-07-31 |
EP1950217 | EP | A1 | 2008-07-30 |