000130532 001__ 130532
000130532 005__ 20190316234442.0
000130532 0247_ $$2doi$$a10.1371/journal.pgen.1000058
000130532 037__ $$aARTICLE
000130532 245__ $$aIdentification of CIITA Regulated Genetic Module Dedicated for Antigen Presentation
000130532 269__ $$a2008
000130532 260__ $$c2008
000130532 336__ $$aJournal Articles
000130532 520__ $$aThe class II trans-activator CIITA is a transcriptional co-activator required for the expression of Major Histocompatibility Complex (MHC) genes. Although the latter function is well established, the global target-gene specificity of CIITA had not been defined. We therefore generated a comprehensive list of its target genes by performing genome-wide scans employing four different approaches designed to identify promoters that are occupied by CIITA in two key antigen presenting cells, B cells and dendritic cells. Surprisingly, in addition to MHC genes, only nine new targets were identified and validated by extensive functional and expression analysis. Seven of these genes are known or likely to function in processes contributing to MHC-mediated antigen presentation. The remaining two are of unknown function. CIITA is thus uniquely dedicated for genes implicated in antigen presentation. The finding that CIITA regulates such a highly focused gene expression module sets it apart from all other transcription factors, for which large-scale binding-site mapping has indicated that they exert pleiotropic functions and regulate large numbers of genes.
000130532 700__ $$aKrawczyk, Michal
000130532 700__ $$aSeguín-Estévez, Queralt
000130532 700__ $$aLeimgruber, Elisa
000130532 700__ $$aSperisen, Peter
000130532 700__ $$aSchmid, Christoph
000130532 700__ $$0244404$$g113607$$aBucher, Philipp
000130532 700__ $$aReith, Walter
000130532 773__ $$j4$$tPlos Genetics$$k4$$qe1000058
000130532 8564_ $$zURL
000130532 8564_ $$uhttps://infoscience.epfl.ch/record/130532/files/pgen.1000058.pdf$$zn/a$$s759407
000130532 909C0 $$xU11780$$0252244$$pGR-BUCHER
000130532 909CO $$qGLOBAL_SET$$pSV$$ooai:infoscience.tind.io:130532$$particle
000130532 937__ $$aGR-BUCHER-ARTICLE-2008-003
000130532 973__ $$rREVIEWED$$sPUBLISHED$$aEPFL
000130532 980__ $$aARTICLE