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Abstract

Multiple refocusing cycles can be used to extract transverse relaxation rates, R2, while homonuclear scalar couplings do not interfere. In this work, I have demonstrated the usefulness of a hybrid sequence, which is a compromise between single and multiple refocusing sequences, in order to investigate homonuclear scalar coupled spin systems, and to find a regime where the decays used to extract transverse relaxation rates are not modulated by cosine functions due to J-couplings. It was possible to measure the transverse relaxation rates of carbon-13 in doubly-enriched glycine and compare them with those of carbon-13 in singly-enriched glycine samples, which were in good agreement, and confirmed the feasibility of extracting R2 rates in coupled spin systems. I also investigated spin systems with more than one J-coupling interaction, and showed by experiments and numerical simulations that the increased complexity of the system reduces the possibilities of extracting unmodulated decays.

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