Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds
2008
Abstract
The water-sol. complexes [(Cp'OR)RuCl(PTA)2] (Cp'OR = h5-1-alkoxy-2,4-di-tert-butyl-3-neopentylcyclopentadienyl; R = Me, Et; PTA = 1,3,5-triaza-7-phosphaadamantane) are considerably more cytotoxic (.apprx.2 orders of magnitude) than the cyclopentadienyl analog [CpRuCl(PTA)2] (i.e., IC50 = 4-10 vs. >1000 mM, depending on the cell line). The structure of [(Cp'OMe)RuCl(PTA)2] is reported, together with that of the precursor [(Cp'OEt)Ru(m-Cl)]2.
Details
Title
Importance of the p-Ligand: Remarkable Effect of the Cyclopentadienyl Ring on the Cytotoxicity of Ruthenium PTA Compounds
Author(s)
Dutta, Barnali ; Scolaro, Claudine ; Scopelliti, Rosario ; Dyson, Paul J. ; Severin, Kay.
Published in
Organometallics
Volume
27
Issue
7
Pages
1355-1357
Date
2008
Other identifier(s)
View record in Web of Science
DAR: 12665
DAR: 12665
Record Appears in
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCOM - Laboratory of Organometallic and Medicinal Chemistry
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCS - Laboratory of Supramolecular Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Scientific production and competences > SB - School of Basic Sciences > ISIC - Institute of Chemical Sciences and Engineering > LCS - Laboratory of Supramolecular Chemistry
Peer-reviewed publications
Work produced at EPFL
Journal Articles
Published
Record creation date
2008-07-29