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  4. Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis
 
research article

Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis

Inoue-Narita, Tae
•
Hamada, Koichi
•
Sasaki, Takehiko
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2008
Cancer Research

Phosphate and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor gene inactivated in numerous sporadic cancers, including melanomas. To analyze Pten functions in melanocytes, we used the Cre-loxP system to delete Pten specifically in murine pigment-producing cells and generated DctCrePten(flox/flox) mice. Half of DctCrePten(flox/flox) mice died shortly after birth with enlargements of the cerebral cortex and hippocampus. Melanocytes were increased in the dermis of perinatal DctCrePten(flox/flox) mice. When the mutants were subjected to repeated depilations, melanocyte stem cells in the bulge of the hair follicle resisted exhaustion and the mice were protected against hair graying. Although spontaneous melanomas did not form in DctCrePten(flox/flox) mice, large nevi and melanomas developed after carcinogen exposure. DctCrePten(flox/flox) melanocytes were increased in size and exhibited heightened activation of Akt and extracellular signal-regulated kinases, increased expression of Bcl-2, and decreased expression of p27(Kip1). Our results show that Pten is important for the maintenance of melanocyte stem cells and the suppression of melanomagenesis

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Type
research article
DOI
10.1158/0008-5472.CAN-08-0889
Web of Science ID

WOS:000257768300033

Author(s)
Inoue-Narita, Tae
Hamada, Koichi
Sasaki, Takehiko
Hatakeyama, Sachiko
Fujita, Sachiko
Kawahara, Kohichi
Sasaki, Masato
Kishimoto, Hiroyuki
Eguchi, Satoshi
kojima, Itaru
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Date Issued

2008

Published in
Cancer Research
Volume

68

Issue

14

Start page

5760

End page

5768

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
GR-BEERMANN  
Available on Infoscience
July 21, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/27056
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