Nanomosaic Network for the Detection of Proteins Without Direct Electrical Contact

A nanomosaic network of metallic nanoparticles for the detection of ultralow concentrations of proteins is reported, which uses two planar microelectrodes embedded in a microchip that permit generation of capacitive coupling to the nanomosaic system without the need for direct electrical contact with the channel. By tailoring the microchannel surface using a sandwich configuration of polyethylene terephthalate/gold nanoparticles/poly(L-lysine), the surface charge can be modified following biomolecular interactions and monitored using a noncontact admittance technique. This nanodevice system behaves like a tunable capacitor and can be employed for the detection of any kind of molecule. The femtomolar detection of an anionic protein, such as b- lactoglobulin in phosphatebuffered saline medium, is taken as an example.


Published in:
Small, 4, 6, 802-809
Year:
2008
Publisher:
Wiley-Blackwell
ISSN:
1613-6810
Keywords:
Laboratories:




 Record created 2008-05-21, last modified 2018-09-13

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