Preparation and synthetic applications of 8-oxabicyclo[3.2.1]oct-6-en-3-one derivatives

The development of efficient routes to multi gram quantities of chiral synthons is a key issue in total synthesis of natural products and analogues. The conformationally defined and rigid 8-oxabicyclo[3.2.1]oct-6-en-3-one template appears as an appealing starting material for the development of non iterative approaches to polyoxygenated fragments that are found in a large variety of biologically relevant natural compounds. Desymmetrization and resolution procedures, stereoselective functionalizations and double-chain elongations represent attractive strategies for such synthetic challenges.


Published in:
Chimia, 62, 221-225
Year:
2008
Keywords:
Laboratories:




 Record created 2008-05-20, last modified 2018-03-17


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