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  4. Genetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance
 
review article

Genetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance

Kondo, T.
•
Herault, Y.
•
Zakany, J.
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1998
Molecular and Cellular Endocrinology

Over the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which have accompanied the fin-to-limb transition, an evolutionary step of critical importance which opened the way to the evolution of higher vertebrates. This convergence between developmental biology and the sciences of evolution is one of the synergistic interface that has been established recently thanks to the use of genetic engineering and transgenic animals. The increasing number of human genetic syndromes which are derived from mutations in developmental control genes remind us that many human genetic diseases are nothing else but alterations in our developmental programme. Here, we illustrate these various issues by discussing the function of Hox genes during limb development

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Type
review article
DOI
10.1016/S0303-7207(98)00021-5
Author(s)
Kondo, T.
Herault, Y.
Zakany, J.
Duboule, D.  
Date Issued

1998

Published in
Molecular and Cellular Endocrinology
Volume

140

Issue

1-2

Start page

3

End page

8

Note

Department of Zoology and Animal Biology, University of Geneva, Sciences III, Switzerland

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPDUB  
Available on Infoscience
February 27, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/19425
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