Repository logo

Infoscience

  • English
  • French
Log In
Logo EPFL, École polytechnique fédérale de Lausanne

Infoscience

  • English
  • French
Log In
  1. Home
  2. Academic and Research Output
  3. Journal articles
  4. Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells
 
research article

Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells

Kmita, M.
•
Tarchini, B.
•
Duboule, D.  
Show more
2002
Development

Transcriptional regulation of vertebrate Hox genes involves enhancer sequences located either inside or outside the gene clusters. In the mouse Hoxd complex, for example, series of contiguous genes are coordinately controlled by regulatory sequences located at remote distances. However, in different cellular contexts, Hox genes may have to be insulated from undesirable external regulatory influences to prevent ectopic gene activation, a situation that would likely be detrimental to the developing embryo. We show the presence of an insulator activity, at one extremity of the Hoxd complex, that is composed of at least two distinct DNA elements, one of which is conserved throughout vertebrate species. However, deletion of this element on its own did not detectably affect Hoxd gene expression, unless another DNA fragment located nearby was removed in cis. These results suggest that insulation of this important gene cluster relies, at least in part, upon a sequence-specific mechanism that displays some redundancy.

  • Details
  • Metrics
Type
research article
DOI
10.1242/dev.00151
Author(s)
Kmita, M.
Tarchini, B.
Duboule, D.  
Herault, Y.
Date Issued

2002

Published in
Development
Volume

129

Issue

23

Start page

5521

End page

8

Note

Department of Zoology and Animal Biology, University of Geneva, Sciences III, Quai Ernest Ansermet 30, Switzerland.

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPDUB  
Available on Infoscience
February 25, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/19230
Logo EPFL, École polytechnique fédérale de Lausanne
  • Contact
  • infoscience@epfl.ch

  • Follow us on Facebook
  • Follow us on Instagram
  • Follow us on LinkedIn
  • Follow us on X
  • Follow us on Youtube
AccessibilityLegal noticePrivacy policyCookie settingsEnd User AgreementGet helpFeedback

Infoscience is a service managed and provided by the Library and IT Services of EPFL. © EPFL, tous droits réservés