The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.
Type
research article
Authors
Publication date
1991
Published in
Volume
350
Issue
6319
Start page
585
End page
9
Note
European Molecular Biology Laboratory, Heidelberg, Germany.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
February 25, 2008
Use this identifier to reference this record