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  4. Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene
 
research article

Primary structure and embryonic expression pattern of the mouse Hox-4.3 homeobox gene

Izpisua-Belmonte, J. C.
•
Dolle, P.
•
Renucci, A.
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1990
Development

We report the cloning, genomic localization, primary structure and developmental expression pattern of the novel mouse Hox-4.3 gene. This gene is located within the HOX-4(5) complex, at a position which classifies it as a member of the Hox-3.1 and -2.4 subfamily, the DNA and predicted protein sequences further confirmed this classification. Hox-4.3 has a primary structure characteristic of a Hox gene but, in addition, contains several monotonic stretches of amino acids, one of the 'paired'-like type. As expected from its presence and position within the complex. Hox-4.3 is developmentally expressed in structures of either mesodermal or neurectodermal origin located or derived from below a precise craniocaudal level. However, a very important offset between anteroposterior boundaries within neuroectoderm versus mesoderm derivatives is observed. Like other genes of the HOX-4(5) complex, Hox-4.3 is expressed in developing limbs and gonads, suggesting that 'cluster specificity' could be a feature of the HOX network.

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Type
research article
Author(s)
Izpisua-Belmonte, J. C.
Dolle, P.
Renucci, A.
Zappavigna, V.
Falkenstein, H.
Duboule, D.  
Date Issued

1990

Published in
Development
Volume

110

Issue

3

Start page

733

End page

45

Note

EMBL, Heidelberg, FRG.

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
UPDUB  
Available on Infoscience
February 25, 2008
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/19140
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