Role of Ets-1 in erythroid differentiation

Members of the Ets gene family are known to be expressed in the hematopoietic tissue and some of them play a pivotal role in normal hematopoietic cell development. Ets-1 gene expression was analyzed in Friend Leukemia Cells (FLC) induced to erythroid differentiation by DMSO. We show that the level of Ets-1 protein and its binding activity decreases in FLC along erythroid differentiation of primary human progenitors. The same behavior was observed during normal erythroid differentiation. Moreover, FLC constitutively expressing Ets-1 show a decrease in TfR gene expression, globin mRNA and hemoglobin synthesis. These data indicate that a decrease in Ets-1 binding activity is required for a normal erythroid maturation and that a deregulated expression of this transcription factor may interfere with terminal erythroid differentiation.

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Blood Cells Mol Dis, 29, 3, 553-61
Laboratory of Virology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy. (Invited paper)

 Record created 2008-02-25, last modified 2018-07-07

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