Deletion of beta-catenin impairs T cell development

T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the alphabeta TCR. Here we show that T cell-specific deletion of beta-catenin impaired T cell development at the beta-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development.


Published in:
Nat Immunol, 4, 12, 1177-82
Year:
2003
Note:
Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.
Laboratories:




 Record created 2008-02-18, last modified 2018-03-17


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