Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin


Published in:
Curr Opin Cell Biol, 6, 5, 711-716
Year:
1994
Note:
Author address: Max-Delbruck-Center for Molecular Medicine, Berlin, Germany
Laboratories:




 Record created 2008-02-13, last modified 2018-03-17


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