Infoscience

Review

Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin

    Note:

    Author address: Max-Delbruck-Center for Molecular Medicine, Berlin, Germany

    Reference

    • CDTSO-REVIEW-1994-001

    Record created on 2008-02-13, modified on 2016-08-08

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