research article
Analysis of the mouse Scnn1a promoter in cortical collecting duct cells and in transgenic mice
2001
We have isolated and characterised the promoter of the mouse Scnn1a (alpha ENaC) gene. Using transient transfections of serial deletion mutants into Scnn1a-expressing cells, we demonstrate that 1.56 kb of 5' upstream sequence is required for cell-specific expression and corticosteroid-mediated regulation. These 5' sequences are not sufficient to drive expression of a lacZ reporter gene or a rat Scnn1a cDNA in transgenic mice, where they failed to rescue Scnn1a deficiency.
Type
research article
Author(s)
Kohler, S.
•
Pradervand, S.
•
Verdumo, C.
•
Merillat, A. M.
•
Bens, M.
•
Vandewalle, A.
•
•
Hummler, E.
Date Issued
2001
Published in
Volume
1519
Issue
1-2
Start page
106
End page
10
Note
Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland.
Editorial or Peer reviewed
REVIEWED
Written at
OTHER
EPFL units
Available on Infoscience
January 10, 2008
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