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research article

Significant similarity and dissimilarity in homologous proteins

Karlin, S.
•
Brendel, V.
•
Bucher, P.  
1992
Molecular Biology and Evolution

Common practice emphasizes significant sequence similarities between different members of protein families. These similarities presumably reflect on evolutionary conservation of structurally and functionally essential residues. The nonconserved regions, on the other hand, may be either selectively neutral or differentiated. We propose several distributional sequence statistics (e.g., clustering of charged residues, compositional biases, and repetitive patterns) as indicators of differentiation events. These ideas are illustrated with various examples, including comparisons among G protein-coupled receptors, herpesvirus proteins, and GTPase-activating proteins.

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Type
research article
DOI
10.1093/oxfordjournals.molbev.a040704
Author(s)
Karlin, S.
Brendel, V.
Bucher, P.  
Date Issued

1992

Published in
Molecular Biology and Evolution
Volume

9

Issue

1

Start page

152

End page

167

Note

Department of Mathematics, Stanford University, California 94305.

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
GR-BUCHER  
Available on Infoscience
December 17, 2007
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/15656
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