The IFN gamma receptor: A paradigm for cytokine receptor signaling

During the last several years, the mechanism of IFN gamma-dependent signal transduction has been the focus of intense investigation. This research has recently culminated in the elucidation of a comprehensive molecular understanding of the events that underlie IFN gamma-induced cellular responses. The structure and function of the IFN gamma receptor have been defined. The mechanism of IFN gamma signal transduction has been largely elucidated, and the physiologic relevance of this process validated. Most recently, the molecular events that link receptor ligation to signal transduction have been established. Together these insights have produced a model of IFN gamma signaling that is nearly complete and that serves as a paradigm for signaling by other members of the cytokine receptor superfamily.

Published in:
Annual Review of Immunology, 15, 563-591
Bach, E. A. Washington Univ,Sch Med,Ctr Immunol,St Louis,Mo 63110 Washington Univ,Sch Med,Dept Pathol,St Louis,Mo 63110 Swiss Inst Expt Canc Res,Isrec,Ch-1066 Epalinges,Switzerland

 Record created 2007-12-12, last modified 2020-07-30

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