Antiviral Protection by Vesicular Stomatitis Virus-Specific Antibodies in Alpha/Beta Interferon Receptor-Deficient Mice

The role of innate, alpha/beta interferon (IFN-alpha/beta)-dependent protection versus specific antibody-mediated protection against vesicular stomatitis virus (VSV) was evaluated in IFN-alpha/beta receptor-deficient mice (IFN-alpha/beta R(0/0) mice). VSV is a close relative to rabies virus that causes neurological disease in mice. In contrast to normal mice, IFN-alpha/beta R(0/0) mice were highly susceptible to infection with VSV because of ubiquitous high viral replication. Adoptive transfer experiments showed that neutralizing antibodies against the glycoprotein of VSV (VSV-G) protected these mice efficiently against systemic infection and against peripheral subcutaneous infection but protected only to a limited degree against intranasal infection with VSV. In contrast, VSV-specific T cells or antibodies specific for the nucleoprotein of VSV (VSV-N) were unable to protect IFN-alpha/beta R(0/0) mice against VSV. These results demonstrate that mice are extremely sensitive to VSV if IFN-alpha/beta is not functional and that under these conditions, neutralizing antibody responses mediate efficient protection, but apparently only against extraneuronal infection.

Published in:
Journal of Virology, 69, 4, 2153-2158
Steinhoff, U. Univ Zurich,Inst Exptl Immunol,Dept Pathol,Sternwartstr 2,Ch-8091 Zurich,Switzerland Univ Zurich,Inst Molek Biol 1,Ch-8057 Zurich,Switzerland

 Record created 2007-12-12, last modified 2020-07-30

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