Cd40 Ligand Has Potent Antiviral Activity

For B cells to make antibodies against most antigens, they require help from T cells. T cell help is delivered as two signals to the B cell, one of which is via CD40 and the other can be through receptors for any of a variety of soluble cytokines. We have constructed recombinant vaccinia viruses that express the ligand for CD40 and have shown that the growth of these viruses is dramatically controlled in vivo, even in mice that lack T or B cells. In this paper, we also describe our attempts to analyse the CD40 ligand-mediated antiviral activity by studying the clearance of these viruses in mice that are deficient in important antiviral mechanisms. Thus, the antiviral activity of CD40L may represent a surprising and potent effector mechanism of T cells activated during a virus infection.

Published in:
Nature Medicine, 1, 5, 437-441
Ruby, J. John Curtin Sch Med Res,Div Cell Biol,Viral Engn & Cytokines Grp,Pob 334,Canberra,Act 2601,Australia F Hoffmann La Roche & Co Ltd,Pharmaceut Res New Technol,Dept Biol,Ch-1002 Basel,Switzerland Genentech Inc,S San Francisco,Ca 94080

 Record created 2007-12-12, last modified 2020-07-30

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