Infoscience

Journal article

Inducible gene targeting in mice

A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented. The method uses an interferon-responsive promoter to control the expression of Cre recombinase. Here, Cre was used to delete a segment of the DNA polymerase beta gene flanked by IoxP recombinase recognition sites. Deletion was complete in liver and nearly complete in lymphocytes within a few days, whereas partial deletion was obtained in other tissues. This method can be used for the inducible inactivation of any other gene in vivo.

    Note:

    Institute for Genetics, University of Cologne, Germany.

    Reference

    • UPAGU-ARTICLE-1995-011

    Record created on 2007-12-12, modified on 2016-08-08

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