Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.
Type
research article
Authors
Muller, U.
•
Steinhoff, U.
•
Reis, L. F.
•
Hemmi, S.
•
Pavlovic, J.
•
Zinkernagel, R. M.
•
Publication date
1994
Published in
Volume
264
Issue
5167
Start page
1918
End page
1921
Note
Institute of Molecular Biology I, University of Zurich, Switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 12, 2007
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