Functional role of type I and type II interferons in antiviral defense

Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.


Published in:
Science, 264, 5167, 1918-21
Year:
1994
Note:
Institute of Molecular Biology I, University of Zurich, Switzerland.
Laboratories:




 Record created 2007-12-12, last modified 2018-03-17


Rate this document:

Rate this document:
1
2
3
 
(Not yet reviewed)