PrPC is a host protein anchored to the outer surface of neurons and to a lesser extent of lymphocytes and other cells. The transmissible agent (prion) responsible for scrapie is believed to be a modified form of PrPC. Mice homozygous for disrupted PrP genes have been generated. Surprisingly, they develop and behave normally for at least seven months, and no immunological defects are apparent. It is now feasible to determine whether mice devoid of PrPC can propagate prions and are susceptible to scrapie pathogenesis.
Type
research article
Authors
Bueler, H.
•
Fischer, M.
•
Lang, Y.
•
Bluethmann, H.
•
Lipp, H. P.
•
DeArmond, S. J.
•
Prusiner, S. B.
•
•
Weissmann, C.
Publication date
1992
Published in
Volume
356
Issue
6370
Start page
577
End page
82
Note
Institut fur Molekularbiologie I, Universitat Zurich, Switzerland.
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
December 12, 2007
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