research article

Low- to high-throughput analysis of telomerase modulators with Telospot

Cristofari, G.
•
Reichenbach, P.
•
Regamey, P. O.
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2007
Nature Methods

We designed a method termed Telospot to discover and characterize telomerase modulators as anticancer drugs or chemical biology tools. Telospot is based on a highly efficient human telomerase expression system and the detection of telomerase DNA reaction products in macroarray format. Telospot offers a highly scalable, cost- and time-effective alternative to presently available telomerase assays, which are limited by the requirement for PCR, telomerase purification or technologies not amenable to high throughput.

Type
research article
DOI
10.1038/nmeth1099
Web of Science ID

WOS:000249778200021

Author(s)
Cristofari, G.
Reichenbach, P.
Regamey, P. O.
Banfi, D.
Chambon, Marc  

EPFL

Turcatti, G.  
Lingner, J.  
Date Issued

2007

Published in
Nature Methods
Volume

4

Issue

10

Start page

851

End page

853

Note

[1] Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland. [2] Ecole Polytechnique Federale de Lausanne, School of Life Sciences, Station 15, CH-1015 Lausanne, Switzerland. [3] "Frontiers in Genetics" National Center for Competence in Research, quai Ernest-Ansermet 30, CH-1211 Geneva, Switzerland. [4] Present address: Institut National de la Sante et de la Recherche Medicale (INSERM), U758, Ecole Normale Superieure de Lyon, 46 allee d'Italie, F-69364 Lyon, France. [5] These authors contributed equally to this work.

Editorial or Peer reviewed

REVIEWED

Written at

EPFL

EPFL units
PTCB  
UPLIN  
Available on Infoscience
November 20, 2007
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/14810