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research article
Telomerase and chromosome end maintenance
The past year has seen significant advances in our understanding of telomerase and other factors involved in chromosome end maintenance. The protein subunit of telomerase that provides the active site for telomeric DNA synthesis was identified in ciliates, yeast and mammals. It is structurally related to reverse transcriptase and thus represents the first member of this protein family with an essential cellular function. Telomere DNA-binding proteins that may mediate the interaction of telomerase with telomeres have been identified and further characterized in diverse eukaryotes. A further elucidation of telomeric DNA structure has influenced our view of how telomeres replicate.
Type
research article
Authors
Publication date
1998
Published in
Volume
8
Issue
2
Start page
226
End page
32
Peer reviewed
REVIEWED
EPFL units
Available on Infoscience
November 20, 2007
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