Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C
Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.
- Ranked among the top most accessed papers in Angewandte Chemie in October 2007. - Highlighted in Synfacts 2008, (4), 342. http://www.thieme- connect.com/ejournals/html/synfacts/doi/10.1055/s-2008-1042891 - Discussed on Totallysynthetic.com. Spectra: http://www.mynmrdb.org/search/entryid/421645.html
Record created on 2007-09-02, modified on 2016-08-08