Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.


Published in:
Angewandte Chemie, International Edition, 46, 45, 8707-8710
Year:
2007
Keywords:
Note:
- Ranked among the top most accessed papers in Angewandte Chemie in October 2007. - Highlighted in Synfacts 2008, (4), 342. http://www.thieme- connect.com/ejournals/html/synfacts/doi/10.1055/s-2008-1042891 - Discussed on Totallysynthetic.com. Spectra: http://www.mynmrdb.org/search/entryid/421645.html
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Note: The status of this file is: EPFL only


 Record created 2007-09-02, last modified 2018-03-17

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