Switch-peptides as tool for the study of fibrillogenesis

The invention discloses a method for the manuf. of a peptidic folding precursor (switch-peptide) stable and sol. at physiol. conditions, derived from a peptide having a potential for self-assembling and fibrillogenesis. Another object of the invention is to provide a tool for the quant., controlled in vitro study of fibrillogenesis and its inhibition of peptides involved in degenerative diseases. Prepn. of peptides is described.


Year:
2006
Keywords:
Functional groups (Nvoc; switch-peptides for study of fibrillogenesis and for drug screening) ; Enzymes Role: BUU (Biological use ; unclassified) ; CAT (Catalyst use) ; BIOL (Biological study) ; USES (Uses) (Phenacylase; switch-peptides for study of fibrillogenesis and for drug screening) ; Oligomers Role: ADV (Adverse effect ; including toxicity) ; BSU (Biological study ; unclassified) ; PRP (Properties) ; BIOL (Biological study) (and plaques; switch-peptides for study of fibrillogenesis and for drug screening) ; Peptides Role: BUU (Biological use ; unclassified) ; PRP (Properties) ; THU (Therapeutic use) ; BIOL (Biological study) ; USES (Uses) (compds.; switch-peptides for study of fibrillogenesis and for drug screening); Disease (degenerative; switch-peptides for study of fibrillogenesis and for drug screening) ; Proteins Role: ADV (Adverse effect ; including toxicity) ; BSU (Biological study ; unclassified) ; BIOL (Biological study) (huntingtin; switch-peptides for study of fibrillogenesis and for drug screening) ; Polymerization (oligomerization; switch-peptides for study of fibrillogenesis and for drug screening); Solid phase synthesis (peptide; switch-peptides for study of fibrillogenesis and for drug screening) ; Aggregation ; Chemical library ; Conformation ; Conformational transition ; Drug screening ; Fibril ; Photolysis ; Self-assembly ; pH ; beta-Sheet (switch-peptides for study of fibrillogenesis and for drug screening) ; Prion proteins Role: ADV (Adverse effect ; including toxicity) ; BSU (Biological study ; unclassified) ; BIOL (Biological study) (switch-peptides for study of fibrillogenesis and for drug screening) ; Amino acids Role: BSU (Biological study ; unclassified) ; BIOL (Biological study) (switch-peptides for study of fibrillogenesis and for drug screening) ; Enzymes Role: BUU (Biological use ; unclassified) ; CAT (Catalyst use) ; BIOL (Biological study) ; USES (Uses) (switch-peptides for study of fibrillogenesis and for drug screening) ; Peptides Role: BUU (Biological use ; unclassified) ; PRP (Properties) ; THU (Therapeutic use) ; BIOL (Biological study) ; USES (Uses) (switch-peptides for study of fibrillogenesis and for drug screening) ; Acyl groups (transfer; switch-peptides for study of fibrillogenesis and for drug screening) ; Amyloid Role: ADV (Adverse effect ; including toxicity) ; BSU (Biological study ; unclassified) ; BIOL (Biological study) (beta-; switch-peptides for study of fibrillogenesis and for drug screening) ; degenerative disease drug screening switch peptide; switch peptide self assembly fibrillogenesis
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 Record created 2007-07-31, last modified 2018-01-27


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