Clinical imaging fluorescence apparatus for the endoscopic photodetection of early cancers by use of Photofrin II
A fluorescence imaging device applied to the detection of early cancer is described. The app. is based on the imaging of laser-induced fluorescence of a dye that localizes in a tumor with a higher concn. than in the surrounding normal tissue after i.v. injection. Tests carried out in the upper aerodigestive tract, the tracheobronchial tree, and the esophagus with Photofrin II (1 mg/kg of body wt.) as the fluorescent agent are reported as examples. The fluorescence is induced by violet (410-nm) light from a continuous-wave (cw) krypton-ion laser. The fluorescence contrast between tumor and surrounding tissue is enhanced by real-time image processing. This is done by the simultaneous recording of the fluorescence image in two spectral domains (470-600 and 600-720 nm), after which these two images are digitized and manipulated with a math. operator (look-up table) at video frequency. Among the 7 photodetections performed in the tracheobronchial tree, 6 were successful, whereas it was the case for only 5 of the 15 lesions investigated in squamous mucosa (upper aerodigestive tract and esophagus). The sources of false positives and false negatives are evaluated in terms of the fluorescent dye, tissue optical properties, and illumination optics.
Keywords: Photomedicine group ; 87806-31-3 (Photofrin II) Role: THU (Therapeutic use) ; fluorescence imaging tumor Photofrin II ; BIOL (Biological study) ; USES (Uses) (imaging fluorescence app. for endoscopic photodetection of early cancers using Photofrin II)
Copyright 2003 ACS; CAPLUS; AN 1997:555163; CAN 127:202207; 8-9; Radiation Biochemistry; 14; Institute of Environmental Engineering,Ecole Polytechnique Federale de Lausanne,Lausanne,Switz. FIELD URL:; Journal; APOPAI; written in English.; Imaging (fluorescent; imaging fluorescence app. for endoscopic photodetection of early cancers using Photofrin II); Neoplasm (imaging fluorescence app. for endoscopic photodetection of early cancers using Photofrin II); Laser radiation (laser imaging fluorescence app. for endoscopic photodetection of early cancers using Photofrin II)
Record created on 2007-07-20, modified on 2016-08-08