ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes
Electrospray ionization mass spectrometry allows a rapid characterization of the adducts formed between three novel anticancer ruthenium(II)-arene PTA compds. and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein-bound metallic fragments and the extent of protein metalation was readily obtained.
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Casini, A., Mastrobuoni, G., Ang, W., Gabbiani, C., Pieraccini, G., Moneti, G., Dyson, P., & Messori, L. (2007). ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexes. Chemmedchem, 2(5), 631–635. https://doi.org/10.1002/cmdc.200600258
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2007
2
5
631
635
REVIEWED
EPFL