Effects of methotrexate on transfected DNA stability in mammalian cells

The chromosomal locations, amounts, and level of expression of transfected, amplified c-myc and dihydrofolate reductase sequences were measured in cells cultured in the presence and absence of methotrexate. These studies show that the location and amount of transfected sequences, as well as the level of expression, were more variable when the cells were cultured in methotrexate.


Published in:
Molecular and cellular biology, 10, 1, 401-4
Year:
1990
ISSN:
0270-7306
Keywords:
Note:
Biomedical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550.
Laboratories:




 Record created 2007-06-05, last modified 2018-03-17

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