Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy

To determine whether neurturin (NTN), a recently identified homologue of glial cell line-derived neurotrophic factor (GDNF), is able to preserve tyrosine hydroxylase immunoreactivity (TH-IR) in a rat model of Parkinson's disease, polymer encapsulated cells genetically engineered to release NTN were implanted near the substantia nigra 1 week before a unilateral medial forebrain bundle axotomy. Animals were allowed to survive for 1 week post-axotomy. Upon sacrifice, animals that received a NTN capsule had a significantly higher percentage of TH-IR (lesioned side vs non-lesioned side) than animals that had received a capsule containing non-transfected parent cells. However, in contrast to GDNF, no reduction of turning was observed upon amphetamine rotation with NTN. Nevertheless, these results suggest that NTN might have a therapeutic value for the treatment of Parkinson's disease.


Publié dans:
Neuroreport, 9, 8, 1817-22
Année
1998
ISSN:
0959-4965
Mots-clefs:
Note:
Division of Surgical Research and Gene Therapy Center, CHUV, Lausanne, Switzerland.
Laboratoires:




 Notice créée le 2007-03-09, modifiée le 2018-12-03


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