Amino or Thiol Linker Building Block for the Synthesis of Amino- or Thiol-functionalized nucleic acids and Methods of Making and Use Thereof

An amino or thiol linker building block for the synthesis of amino or thiol functionalized amino acids and generally of the following structure: Formula XII is provided. Such building block may be introduced in the 5' end position of an amino acid under standard coupling conditions. Such building block allows inline coupling control, "trityl-on" purification, and solid support functionalization/derivatization. Such building block is a stable, solid compound and can therefore be easily handled. With the building block of the present invention, deprotection may be carried out under standard detritylation conditions.

Alternative title(s) : (de) Amino- oder thiollinkerbaustein für die synthese von amino- oder thiolfunktionalisierten nukleinsäuren und verfahren zu deren herstellung und anwendung (fr) Bloc de construction de liants amino ou thiol pour la synthese d'acides nucleiques fonctionnalises amino ou thiol et son procede d'obtention et d'utilisation (en) Amino or thiol linker building block for the synthesis of amino- or thiol-functionalized nucleic acids and methods of making and use thereof
Other identifiers:
EPO Family ID: 36228444

 Record created 2007-03-07, last modified 2020-08-31

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