Infoscience

Conference paper

Two-Dimensional Magnetic Droplet Manipulation Platform for Miniaturized Bioanalytical Applications

Lehmann, Ulrike; Vandevyver, Caroline; Parashar, V.K.; DeCourten, Damien; Gijs, M.A.M.
  • Presented at: MEMS 2007, Kobe, Japan, January 21-25, 2007
  • Published in: Technical Digest of the IEEE MEMS 2007, p. 521-524
  • Publication date: 2007

We present a new approach for the manipulation of small liquid samples for the miniaturization of bioanalytical systems. In our system, minute liquid volumes are manipulated via the interaction of a changeable magnetic field and magnetic microparticles contained within aqueous droplets. Our setup enables the easy conversion of macroscopic bioanalytical protocols into the lab-on-a-chip format. Here we present the implementation of a DNA extraction and purification protocol as well as the onchip optical detection of bioactive molecules. In both cases the miniaturization results in a decrease of the reaction and detection time as well as an increase in sensitivity.

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