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  4. Reconstruction of Switching Thresholds in Piecewise-Affine Models of Genetic Regulatory Networks
 
research report

Reconstruction of Switching Thresholds in Piecewise-Affine Models of Genetic Regulatory Networks

Drulhe, S.
•
Ferrari-Trecate, G.
•
de Jong, H.
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2006

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this technical report, we present an approach for the identification of PieceWise-Affine (PWA) models of genetic regulatory networks from experimental data, focusing on the reconstruction of switching thresholds associated with regulatory interactions. In particular, our method takes into account geometric constraints specific to models of genetic regulatory networks. We show the feasibility of our approach by the reconstruction of switching thresholds in a PWA model of the carbon starvation response in the bacterium Escherichia coli.

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Type
research report
Author(s)
Drulhe, S.
Ferrari-Trecate, G.
de Jong, H.
Viari, A.
Date Issued

2006

Editorial or Peer reviewed

REVIEWED

Written at

OTHER

EPFL units
SCI-STI-GFT  
Available on Infoscience
January 10, 2017
Use this identifier to reference this record
https://infoscience.epfl.ch/handle/20.500.14299/132647
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